Helix-helix interactions inside lipid bilayers
نویسندگان
چکیده
منابع مشابه
Lipid-helix interactions in membrane receptors.
The integration of the transmembrane (TM) proteins in the lipid bilayer depend on lipid-protein interactions. The few crystal structures known for multiple membrane spanning proteins suggest a basic form composed of bundles of a-helices that pack together. In the membrane helix-helix and helix-lipid interaction define the helix arrangement in the folded receptor. Thus, the lipid-protein interac...
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Starting from the glycophorin A dimer structure determined by NMR, we performed simulations of both dimer and monomer forms in explicit lipid bilayers with constant normal pressure, lateral area, and temperature using the CHARMM potential. Analysis of the trajectories in four different lipids reveals how lipid chain length and saturation modulate the structural and energetic properties of trans...
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Salt ions are essential for the folding of nucleic acids. We use the tightly bound ion (TBI) model, which can account for the correlations and fluctuations for the ions bound to the nucleic acids, to investigate the electrostatic free-energy landscape for two parallel nucleic acid helices in the solution of added salt. The theory is based on realistic atomic structures of the helices. In monova...
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Atomistic simulations have recently been shown to be sufficiently accurate to reversibly fold globular proteins and have provided insights into folding mechanisms. Gaining similar understanding from simulations of membrane protein folding and association would be of great medical interest. All-atom simulations of the folding and assembly of transmembrane protein domains are much more challengin...
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Transmembrane helices are no longer believed to be just hydrophobic segments that exist solely to anchor proteins to a lipid bilayer, but rather they appear to have the capacity to specify function and structure. Specific interactions take place between hydrophobic segments within the lipid bilayer whereby subtle mutations that normally would be considered innocuous can result in dramatic struc...
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ژورنال
عنوان ژورنال: Current Opinion in Structural Biology
سال: 1992
ISSN: 0959-440X
DOI: 10.1016/0959-440x(92)90080-q